It’s estimated that, during the 1770s, smallpox killed 30% of the total population of the Northwest Coast of America, yielding a body count in the tens of thousands. And from 1770 to 1850, smallpox, measles and influenza killed at least two thirds of the original population of Western Washington.
All in all, from 1500 to 1900, introduced diseases like smallpox, measles and typhoid killed around 1,500,000 Native Americans. It’s therefore probably not an exaggeration to say that these epidemic diseases helped pave the way for Europeans to conquer the New World.
9. Third Cholera Pandemic 1846-1863
One of cholera’s most devastating spells occurred from 1846 to 1863. The infection spread from India to Afghanistan in 1839, and then there were sporadic outbreaks over the next six years before it reappeared in India and the Middle East in 1845. It worked its way across the world to Russia, where it is estimated that it caused at least a million deaths. And by 1848, it was wreaking havoc on Europe. In 1854, more than 23,000 died in Britain alone. It seemed no one was safe, as the disease hit Africa and made its way through the Americas as well.
On the other hand, the London cholera outbreak also played an important role in the founding of epidemiology. In 1854, physician John Snow analyzed cholera’s fatalities and noticed that a large number of cases in Soho were clustered around the pump in Broad Street.
He concluded that the pump’s water was somehow contaminated with “cholera poison” and requested that the local authorities remove its handle. This was one of the first times that modern methods like statistics had been used to combat a disease outbreak. As such, John Snow has been dubbed the “father of modern epidemiology.”
8. Asian Flu 1856-58
The illness made its way to Singapore in February 1957 and within months spread to Hong Kong and the US. By September it had infected India, northern Australia, the Philippines, the UK and continental Europe.
The first waves of the disease infected large numbers of school children. It was estimated that in 1957, 50% of British school children were infected with the virus. In residential schools in the UK, attack rates reached a staggering 90%, and the disease often made its way through an entire school in a couple of weeks.
Worldwide deaths from the outbreak were estimated at around two million. And the fact that a strain of common influenza could cause so many casualties illustrates just how dangerous such a simple disease can be in a global context.
7. Antonine Plague 165-180
Symptoms of the disease included fever, diarrhea and inflammation of the throat, and it was frequently deadly. Although the great Greek physician Galen was present during the plague, his descriptions are sketchy and it is therefore difficult to say exactly which virus was responsible. Most historians, however, agree that the culprit was either measles or smallpox.
Total deaths from the epidemic are estimated at around five million. And due to the combined effects of other outbreaks, such as the Plague of Cyprian, the shrinking population couldn’t produce the military or economic might to sustain the Western Roman Empire. By the third century, the capital city was no longer providing strong central government, and from then on, Imperial power could only go downhill. Just to think: the disintegration of Rome’s global empire, all caused by a handful of germs.
6. Thirty Years’ War Typhus/Plague Epidemic 1618-1648
Soldiers dealing with the unsanitary conditions of 17th-century warfare were perfect hosts for lice – parasites that spread typhus through the ranks of troops. The symptoms of the disease include shivering, chills, nausea, vomiting, and pain in the head, back and chest.
Without medical treatment, typhus was often fatal. It is estimated that around eight million Germans died either from typhus or bubonic plague during the war. Typhus is also infamous as a major cause of the deaths in Nazi concentration camps and for decimating Napoleon’s army when he invaded Russia in 1812.
5. Third Plague Pandemic 1855-1959
Tens of thousands of Chinese citizens died, and when the bacteria reached the port cities of Hong Kong and Guangzhou in 1894, it was able to spread across the world. The infected regions included cities as diverse as Bombay, Cape Town and San Francisco. India was especially badly affected and, together with China, accounted for the bulk of the fatalities.
Advances in medical understanding eventually halted the pandemic: germ theory helped doctors to isolate the virus, and early antibiotics, such as sulfa drugs and streptomycin, allowed them to treat it. It would be the final ride for the bubonic plague’s grim reaper.
4. Plague of Justinian 541-542
As with the Antonine Plague before it, the pandemic would squelch the Byzantine Empire’s burgeoning Imperial power. The disease weakened Constantinople’s forces at a critical point and allowed the Goths to reclaim the initiative and prevent emperor Justinian from reuniting the Eastern and Western Roman kingdoms. The plague’s final death toll is estimated to have been between 25 and 100 million people in Europe and Asia.
This disease was a recurring nightmare for the Byzantine Empire, but after its last eruption in 750 AD, it seemed to be gone forever. Nevertheless, bubonic plague would reappear 600 years later in a truly nightmarish fashion…
3. HIV/AIDS 1981-Present
After coming out of latency, the virus causes sufferers to develop AIDS (Acquired Immunodeficiency Syndrome), which prevents the victim’s immune system from fighting disease and generally leads to death from infections or cancer.
The condition was first observed in America in 1981, but it has since spread across the world. AIDS is particularly common in Sub-Saharan Africa, where as many as 15% of the population are infected in some areas. Since its discovery, HIV/AIDS has caused between 25 and 30 million deaths. There’s a reason governments spent most of the 1980s trying to promote safe sex.
2. Spanish Flu 1918-1919
The so-called Spanish flu was an influenza virus, similar to the common seasonal flu but considerably more deadly. In those severely affected, it caused the skin to turn blue, violent coughing that sometimes tore abdominal muscles, bleeding from the mouth and nose, incontinence, and vomiting. The virus was particularly dangerous to the young and seemingly healthy. And in some cases, victims were reported to die in a matter of hours.
Spanish flu first appeared in force in August 1918, simultaneously attacking the port cities of Boston (USA), Brest (France) and Freetown (Sierra Leone). The virus quickly spread around the world thanks to air and ocean travel, overwhelming doctors and nurses, who were often forced to erect temporary tents to deal with the sheer number of patients. At the height of the outbreak, it is estimated that over 500 million people were infected with the disease.
1. Black Death 1338-1351
The pandemic originated as a bubonic plague outbreak in China in the 1330s and was then spread by the fleas of infected rats. Symptoms included fever, headaches, nausea, painful buboes and rashes.
The plague was initially restricted to Asia, but trading ships brought the illness to Sicily in 1347. From there it ravaged the continent, causing thousands of deaths a day and prompting people to flee the cities to the safety of the countryside.
The disease killed so many in Europe that it created labor shortages, which increased the demand for peasant workers and therefore raised their standard of living. Ironically, then, even the most deadly epidemic of all time could be seen to have had some kind of bright side.
